|
KMID : 0370019960100000073
|
|
Chung-Ang Journal of Pharmacal Sciences
1996 Volume.10 No. 0 p.73 ~ p.77
|
|
|
β-Lactamase inhibitory activity of 6-exomethylene penamsulfone derivatives
|
|
|
|
|
Abstract
|
|
|
|
6-Exomethylene penam derivatives were tested as possible β-lactamase inhibitors. The in vitro β-lactamase inhibitory activities were determined by a spectrophotometric assay using Type Ⅰ, Ⅱ, Ⅲ, Ⅳ and TEM β-lactamase. Their activities were compared with sulbactam, tazobactam and clavulanic acid. The 6-exomethylene sulfone derivatives were more potent than clavulanic acid and sulbactam against Type Ⅳ β-lactamase. The Z-isomers showed stronger activities than the E-isomers against TEM and Type Ⅳ β-lactamase.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|